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B. N. Vedha Hari , Akhila Sravya Dantu , P. Shankarguru , D. Ramya Devi

Abstract

Tabernaemontana divaricata is a common shrub found in the tropical regions and is often used for medicinal purposes, particularly the flowers of the plant. The present study is conducted to compare and identi fy the phytochemical constituents by Thin Layer Chromatography (TLC) and Qualitative Phytochemical analysis and to determine the anthelmentic activity of fresh and dried flower extract of Tabernaemontana divaricata . The extract is obtained using two differ ent methods like cold maceration and hot solvent extraction by using soxhlet apparatus, first with petroleum ether followed by hydroalcohol as solvents. The preliminary phytochemical analysis of the extract indicated the presence of Alkaloids, Flavanoids, Steroids, Proteins, Carbohydrates and Tannins. The Rf value of TLC is calculated and compared with standard values and analysis proved the presence of the phytochemical constituents. The anthelmentic activity studies are performed using Indian earth worms . For this, the concentrated extract is diluted to various concentrations, and the effect of each solution is studied by measuring the time taken for paralysis and death of the earth worms. It is found to show significant anthelmentic activity at various concentrations compared with that of the standard drug Metronidazole.

Keywords

Thin Layer Chromatography, Eudrilus Eugeniae, Eisenia Foetid.

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K. Malarvizhi ¹, D. Ramya Devi ¹, Alfred Raymond ², B. N. Vedha Hari ¹

Affiliations
1 School of Chemical and Biotechnology, SASTRA University, Thanjavur-613401, Tamilnadu, IN
2 Sara Industries-ASD, Coimbatore, Tamilnadu, IN

Abstract

The objective of the work is to formulate, optimize and evaluate "Itraconazole nanosuspension as aerosol foam formulation" for the treatment of skin diseases such as Cellulitis, Erysipelas, Impeigo and Blastomycosis, Histoplasmosis, Onchomycosis, etc. The solubility of poorly soluble itraconazole can be improved through nanosuspension process and also the absorption rate and bioavailability of drug can be enhanced by means of aerosol foam dispersion at the site of application.

Keywords

Itraconazole, Nanosuspension, Wet Milling, Foam.

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